Regulated protein stabilization underpins the functional interplay among basal body components in Trypanosoma brucei
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چکیده
منابع مشابه
Functional interplay between protein arginine methyltransferases in Trypanosoma brucei
Arginine methylation is a common posttranslational modification that has far-reaching cellular effects. Trypanosoma brucei is an early-branching eukaryote with four characterized protein arginine methyltransferases (PRMTs), one additional putative PRMT, and over 800 arginine methylated proteins, suggesting that arginine methylation has widespread impacts in this organism. While much is known ab...
متن کاملProximity Interactions among Basal Body Components in Trypanosoma brucei Identify Novel Regulators of Basal Body Biogenesis and Inheritance
The basal body shares similar architecture with centrioles in animals and is involved in nucleating flagellar axonemal microtubules in flagellated eukaryotes. The early-branching Trypanosoma brucei possesses a motile flagellum nucleated from the basal body that consists of a mature basal body and an adjacent pro-basal body. Little is known about the basal body proteome and its roles in basal bo...
متن کاملProtein Interaction Between Basal Body and Kinetoplast DNA Complex Within Trypanosoma brucei
Trypanosoma brucei is responsible for the disease Human African Trypanosomiasis (HAT), also known as African Sleeping Sickness, in humans as well as N’gana in livestock. Our work was done on the sub-species T. brucei brucei, which is non-pathogenic in humans, and thus safe for undergraduate laboratory research. Trypanosoma brucei is part of a diverse group of flagellated protozoans known as the...
متن کاملProtein isoprenylation in Trypanosoma brucei brucei.
Trypanosoma brucei is a digenetic protozoan parasite presenting a public health hazard in certain areas of Africa; it is transmitted between mammals (bloodstream form (BSF)) by tsetse flies (procyclic form (PCF)). We have an ongoing interest in small GTP proteins in T. brucei, and these are commonly isoprenylated. Many isoprenylated proteins belong to the rab family and include ras; the isopren...
متن کاملNIMA-related kinase TbNRKC is involved in basal body separation in Trypanosoma brucei.
The NIMA-related kinase 2 (NEK 2) has important cell cycle functions related to centriole integrity and splitting. Trypanosoma brucei does not possess centrioles, however, cytokinesis is coupled to basal body separation events. Here we report the first functional characterisation of a T. brucei basal body-cytoskeletal NIMA-related kinase (NRK) protein, TbNRKC. The TbNRKC kinase domain has high ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258,1083-351X
DOI: 10.1074/jbc.ra119.011352